FOSRUF

Indication :

FOSRUF Fosfomycin Tromethamine oral powder
FOSRUF is a broad-spectrum antibiotic formulation containing Fosfomycin Tromethamine, specially developed for the treatment of acute uncomplicated urinary tract infections (UTIs) caused by susceptible bacterial strains.

Manufactured by Moruf Life Sciences, FOSRUF offers a single-dose oral therapy that provides rapid and effective relief from symptoms such as painful urination, burning sensation, and urinary frequency. Its unique mechanism of action targets and eliminates bacteria responsible for urinary infections while maintaining an excellent safety and tolerability profile.

FOSRUF is a preferred choice among healthcare professionals for its convenience, compliance-friendly dosing, and high clinical efficacy, especially in women suffering from uncomplicated UTIs.

Mechanism of Action

Fosfomycin Tromethamine is a derivative of phosphonic acid that acts as a bactericidal antibiotic. It works by inhibiting the bacterial enzyme enolpyruvyl transferase, an essential catalyst in the first step of cell wall synthesis. This inhibition prevents the formation of peptidoglycan, an essential component of bacterial cell walls, leading to cell lysis and bacterial death.

Fosfomycin demonstrates excellent activity against both Gram-positive and Gram-negative uropathogens, including Escherichia coli, Enterococcus faecalis, and Klebsiella pneumoniae. Due to its unique mode of action, it is effective even against multi-drug resistant bacterial strains, including ESBL-producing organisms.

After oral administration, Fosfomycin Tromethamine is rapidly absorbed and excreted unchanged in the urine, achieving high urinary concentrations that persist for up to 48 hours, ensuring prolonged antibacterial activity with just one dose.

Indications for Use

FOSRUF Sachet is indicated for the treatment and prophylaxis of:

• Acute uncomplicated urinary tract infections (UTIs)
• Cystitis (inflammation of the urinary bladder)
• Bacterial infections of the lower urinary tract
• Postoperative or catheter-associated urinary infections (as per clinical advice)
• Prophylactic use before urological procedures to prevent infection

Dosage and Administration

The dosages of this medicine must be prescribed by doctor self medication nd over dose can cause worsening of the condition, some of its recommended dose are : 

• One sachet (containing Fosfomycin Tromethamine) dissolved in half a glass of water, taken on an empty stomach, preferably 2–3 hours before or after meals.
• It should be taken once only, unless otherwise advised by the physician.
• For best results, the patient should urinate before taking the dose to ensure maximal concentration in the bladder.
• Do not repeat the dose unless prescribed by the doctor.

Possible Side Effects

FOSRUF is generally safe and well-tolerated. However, a few mild and transient side effects may occur and if it persists then contact your doctors, such as:

• Diarrhea or mild abdominal discomfort
• Headache or dizziness
• Nausea or indigestion
• Vaginal itching or discharge (rare)
• Hypersensitivity or rash (very rare)

Precautions 

While using this medicine there are certain precaution that must be considered for an effective results and risk free treatment 

• Use under medical supervision only.
• Not recommended for patients with severe renal impairment unless specifically directed.
• Avoid use in children below 12 years unless prescribed.
• Pregnant or lactating women should use only under medical advice.
• Store below 25°C, in a cool, dry place away from direct sunlight.

Storage Instructions 

• Keep the medication awar from heat and wet/damp places , and store in a cool and dry place.
• Keep it away from direct sunlight
• Keep away from children 
• Must ensure the original packing is not broken before using or storing for a longer time.